2021

Swanson NA, Lokareddy RK, Li F, Leptihn S, Pumroy RA, Moiseenkova-Bell VY, Cingolani G. Cryo-EM Structure of the Periplasmic Tunnel of T7 DNA-Ejectosome at 2.70 Å resolution. Molecular Cell (2021) (in press).
doi: 10.1016/j.molcel.2021.06.001

Cui Z, Zhang Y, Kakar KU, Kong X, Li R, Loh B, Leptihn S, Li B. Involvement of non-coding RNAs during infection of rice by Acidovorax oryzae. Environmental Microbiology Reports (2021) 13(4), 540-554
doi: 10.1111/1758-2229.12982

Chen H, Hua X, Liang Q, He J, He J, Wang M, Hong W, We J, Lu B, Leptihn S, Yu Y. BacAnt: A Combination Annotation Server for Bacterial DNA sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements. Frontiers in Microbiology (2021) 12, 2015.
doi: 10.3389/fmicb.2021.649969

Ramesh N, Royam MM, Manohar P, Leptihn S. Application of Bacteriophages and its Endolysin in Aquaculture as a Biocontrol Measure. Biological Control (2021) 160, 104678.
doi: 10.1016/j.biocontrol.2021.104678

Cai H, Zhu Y, Hu D, Li Y, Leptihn S, Loh B, Hua X, Yu Y. Co-harboring of novel hybrid blaKPC−2 plasmid and ICE carrying Tn6203 in multidrug-resistant Pseudomonas aeruginosa. Frontiers in Microbiology (2021) 12,1682.
doi: 10.3389/fmicb.2021.674974

Wang X, Zhang M, Loh B, Leptihn S, Ahmed T, Li B. A Novel NRPS Cluster, Acquired by Horizontal Gene Transfer from Algae, Regulates Siderophore Iron Metabolism in Burkholderia seminalis R456. International Journal of Biological Macromolecules (2021) 182,838-848
doi: 10.1016/j.ijbiomac.2021.04.051

Feng T, Leptihn S, Dong K, Loh B, Zhang Y, Li M, Guo XK, Zelin Cui. JD419, a Staphylococcus aureus phage with a unique morphology and broad host range. Frontiers in Microbiology (Virology) (2021) 12,602902
doi: 10.3389/fmicb.2021.602902

Wang Y, Liang Q, Lu B, Shen H, Liu S, Shi Y, Leptihn S, Li H, Wei J, Liu C, Xiao H, Zheng X, Liu C, Chen H. Whole-genome analysis of probiotic product isolates reveals the presence of genes related to antimicrobial resistance, virulence factors, and toxic metabolites, posing potential health risks. BMC Genomics (2021) 22, 210
doi: 10.1186/s12864-021-07539-9

Manohar P, Leptihn S, Lopes BS, Nachimuthu R. Dissemination of carbapenem resistance and plasmids encoding carbapenemases in Gram-negative bacteria isolated in India. JAC-Antimicrobial Resistance (2021) 3(1) dlab015
doi: 10.1093/jacamr/dlab015

Manohar P, Nachimuthu R, Leptihn S, Anuradha R, Rudi K. Reduced Metagenomic Sequencing (RMS) Approach to Determine the Gut-Associated Phageome in Mother-Child. Human Microbiome Journal (2021) 100078
doi: 10.1016/j.humic.2021.100078

Wei W, Yao X, Zhou W, Wang X, Li C, Lin J, Ma Y, He Q, Leptihn S, and Ouyang H. Advanced Hydrogels for the Repair of Cartilage Defects and Regeneration. Bioactive Materials (2021) 6(4), 998-1011.
doi: 10.1016/j.bioactmat.2020.09.030

2020

Loh B*, Gondil VS*, Manohar P, Khan FM, Yang H, Leptihn S. Encapsulation and Delivery of Therapeutic Phages. Applied and Environmental Microbiology (2020) 87:e01979-20.
doi: 10.1128/AEM.01979-20.

Leptihn S, Welburn SC. Will technology rather than vaccination be the way to control pandemics? Infectious Microbes & Diseases (2020) 2(4), 125-126.
doi: 10.1097/IM9.0000000000000041

Fang J, Zhang L, He J, Zhao M, Loh B, Leptihn S, Yu Y, Hua X. Plasmid dynamics of mcr-1-positive Salmonella spp. in a general hospital in China. Frontiers in Microbiology (2020) 11, 3320.
doi: 10.3389/fmicb.2020.604710

Loh B*, Chen J*, Manohar P, Yu Y, Hua X, Leptihn S. A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. Frontiers in Microbiology (2020) 11, 3055. 
doi: 10.3389/fmicb.2020.579802

Feng T, Leptihn S, Dong K, Loh B, Zhang Y, Li M, Guo X, Cui Z. Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range. bioRxiv (2020) 2020.11.09.370866
doi: 10.1101/2020.11.09.370866

Hua X, Xu Q, He J, Zhang D, Chen Q, Zhang L, Loh B, Leptihn S, Wen Y, Higgins P, Zhou Z, Yu Y. The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China. International Journal of Medical Microbiology (2020) 310(8), 151464.
doi: 10.1016/j.ijmm.2020.151464

Loh B*, Chen J*, Manohar P, Yu Y, Hua X, Leptihn S. A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. bioRxiv (2020) 2020.10.26.355222. 
doi: 10.1101/2020.10.26.355222

Manohar P, Loh B, Leptihn S. Will the overuse of Antibiotics during the Coronavirus pandemic accelerate Antimicrobial resistance? Infectious Microbes & Diseases (2020) 2(3), 87-88.
doi: 10.1097/IM9.0000000000000034

Hua X, Liang Q, He J, Wang M, Hong W, Wu J, Lu B, Leptihn S, Yu Y, Chen H. BacAnt: the combination annotation server of antibiotic resistance gene, insertion sequences, integron, transposable elements for bacterial DNA sequences. bioRxiv (2020) 2020.09.05.284273
doi: 10.1101/2020.09.05.284273

Manohar P, Loh B, Nachimuthu R, Hua X, Welburn SC, Leptihn S. Secondary Bacterial Infections in Patients with Viral Pneumonia. Frontiers in Medicine (2020) 7, 420.
doi: 10.3389/fmed.2020.00420

Manohar P, Loh B, Athira S, Nachimuthu R, Hua X, Welburn SC, Leptihn S. Secondary Bacterial Infections during Pulmonary Viral Disease: Phage Therapeutics as Alternatives to Antibiotics? Frontiers in Microbiology (2020) 11, 1434.
doi: 10.3389/fmicb.2020.01434

Hua X, Zhang L, He J, Leptihn S, Yunsong Yu. Population biology and epidemiological studies of Acinetobacter baumannii in the era of Whole Genome Sequencing: Is the Oxford scheme still appropriate? Frontiers in Microbiology (2020) 11, 775.
doi: 10.3389/fmicb.2020.00775

Loh B and Leptihn S: A call for a multidisciplinary future of Phage Therapy to combat multi-drug resistant bacterial infections. Infectious Microbes & Diseases (2020) 2(1), 1-2.
doi: 10.1097/IM9.0000000000000018

Hua X, Liang Q, Fang L, He J, Wang M, Hong W, Leptihn S, Wang H, Yu Y, and Chen H: Bautype-Capsule and Lipopolysaccharide Serotype Prediction for Acinetobacter baumannii Genomes. Infectious Microbes & Diseases (2020) 2(1), 18-25.
doi: 10.1097/IM9.0000000000000019

Feng T, Leptihn S, Li M, Guo M, Gao J, Li Q, Zeng L, Zhou Y, Wei Y, Guo X, Temperton N, Cui Z. Feasibility for SARS-CoV-2 Tests in the Hospital: An Exposure Analysis of Critical Control Points Approach. Research Square (2020)
doi: 10.21203/rs.3.rs-33080/v1

Shi Y, Hua X, Xua Q, Yang Y, Zhang L, He J, Mu X, Hu L, Leptihn S, Yu Y: Mechanism of eravacycline resistance in Acinetobacter baumannii mediated by a deletion mutation in the sensor kinase adeS, leading to elevated expression of the efflux pump AdeABC. Infection, Genetics and Evolution (2020), 80, 104185.
doi: 10.1016/j.meegid.2020.104185

Hu L, Shi Y, Xu Q, Zhang L, He J, Jiang Y, Liu L, Leptihn S, Yu Y, Hua X, Zhou Z: Capsule thickness, not biofilm formation, gives rise to mucoid Acinetobacter baumannii phenotypes that are more prevalent in long-term infections. A study of clinical isolates from a hospital in China. Infection and Drug Resistance (2020) 13, 99—109.
doi: 10.2147/IDR.S230178

Zhao K, Liu YS, Nie LY, Qian LN, Nie NF, Leptihn S, Bunpetch V, Xu JQ, Zhou XH, Ouyang H: The Influence of Sample Size and Gender Composition on the Meta-analysis Conclusion of Platelet-Rich Plasma Treatment for Osteoarthritis Journal of Orthopaedic Translation (2020) 22, 34-42.
doi: 10.1016/j.jot.2019.10.002

2019

Kuhn A. and Leptihn S: Helical and Filamentous Phages. Encyclopaedia of Virology (2019) 
Hardcover ISBN: 9780122270307 ; eBook ISBN: 9780080547978
doi: 10.1016/B978-0-12-809633-8.20986-2

Leptihn S: Welcome back to the Pre-Penicillin Era. Why we desperately need new strategies in the battle against bacterial pathogens. Infectious Microbes & Diseases (2019) 1(2), 33.
doi: 10.1097/IM9.0000000000000009

Manohar P, Tamhankar AJ, Leptihn S, and Ramesh N: Pharmacological and Immunological Aspects of Phage Therapy. Infectious Microbes & Diseases (2019) 1(2), 34-42.
doi: 10.1097/IM9.0000000000000013

Xu Q, Chen T, Yan B, Zhang L, Pi B, Yang Y, Zhang L, Zhou Z, Ji S, Leptihn S, Akova M, Yu Y, Hua X: Dual role of gnaA in antibiotic resistance and virulence in Acinetobacter baumannii. Antimicrobial Agents Chemotherapy (2019) 23, 63(10).
doi: 10.1128/AAC.00694-19

Loh B, Kuhn A and Leptihn S: The fascinating biology behind phage display: Filamentous Phage Assembly. Molecular Microbiology (2019) 111(5), 1132.
doi: 10.1111/mmi.14187

Volk V, Glück C, Leptihn S, Ewert J, Stressler T and Fischer L: Two heat resistant endopeptidases from Pseudomonas species with destabilizing potential during milk storage. Journal of Agricultural and Food Chemistry (2019)  67, 905.
doi: 10.1021/acs.jafc.8b04802

2018

Mueller P, Gauttam R, Raab N, Handrick R, Wahl C, Leptihn S, Zorn M, Kussmaul M, Scheffold M, Eikmanns B, Elling L, Gaisser S: High level in vivo mucin-type glycosylation in Escherichia coli Microbial Cell Factories (2018) 17(1), 168.
doi: 10.1186/s12934-018-1013-9

Stressler T, Reichenberger K, Glück C, Leptihn S, Pfannstiel J, Swietalski P, Kuhn A, Seitl I, Fischer L.: A natural variant of arylsulfatase from Kluyveromyces lactis shows no formylglycine modification and has no enzyme activity. Appl Microbiol Biotechnol. (2018) 102(6), 2709.
doi: 10.1007/s00253-018-8828-5

Ernst I, Haase M, Ernst S, Yuan S, Kuhn A, and Leptihn S: Large conformational changes of a highly dynamic pre-protein binding domain in SecA. Communications Biology (2018) 1 (1), 130.
doi: 10.1038/s42003-018-0133-4

Gras C, Bause K, Leptihn S, Carle R, Schweiggert RM: Effect of chlorogenic acid on spectral properties and stability of acylated and non-acylated cyanidin-3-O-glycosides. Elsevier Food Chemistry (2018) 240, 940. 
doi: 10.1016/j.foodchem.2017.07.137

2017

Leptihn S: Interaction of Polypeptides with Phospholipid Membranes (Habilitation) Monograph (2017)

Kuhn A, Haase M, and Leptihn S: Assisted and unassisted protein insertion into liposomes. Biophysical Journal (2017) 113 (6), 1187
doi: 10.1016/j.bpj.2017.03.027

Loh B, Haase M, Mueller L, Kuhn A, and Leptihn S: The transmembrane morphogenesis protein gp1 of filamentous phages contains Walker A and Walker B motifs essential for phage assembly. Viruses (2017) 9 (4), 73. 
doi: 10.3390/v9040073

Altrichter S, Haase M, Loh B, Kuhn A and Leptihn S: Mechanism of the Spontaneous and Directional Insertion of a 2-Transmembrane Ion Channel. ACS Chemical Biology (2017) 12 (2), 380-388. 
doi: 10.1021/acschembio.6b01085

2016

Meyer M, Leptihn S, Welz M, and Schaller A: Functional characterization of propeptides in plant subtilases as molecular chaperones and inhibitors of the mature protease.  Journal of Biological Chemistry (2016) 291 (37), 19449-61.
doi: 10.1074/jbc.M116.744151 

Utturkar S, Huber H, Leptihn S, Loh B, Brown S, Stetter KO and Podar M: Draft-Genome sequence of Pyrodictium occultum PL-19, a marine hyperthermophilic species of Archaea that grows at 105˚C. American Society for Microbiology: Genome Announcements (2016) 25 4(1). 
doi: 10.1128/genomeA.00016-16

Leptihn S*, Gottschalk J, and Kuhn A. The T7 Ejectosome: A story unfolds. Bacteriophage (2016), 6, 1. * corresponding author.
doi: 10.1080/21597081.2015.1128513

Hempel J, Schaedle C, Leptihn S, Carle R, and Schweiggert RM: Structure related aggregation behavior of carotenoids and carotenoids esters. Journal of Photochemistry and Photobiology A: Chemistry (2016) 317, 161-174.
doi: 10.1016/j.jphotochem.2015.10.024

2015

Lupo D, Leptihn S, Nagler G, Haase M, Molineux IJ, and Kuhn A: The T7 ejection nanomachine components gp15-gp16 form a spiral ring complex that binds DNA and a lipid membrane. Virology (2015) 14(486), 263-271.
doi: 10.1016/j.virol.2015.09.022

Stellmacher L, Sandalova T, Leptihn S, Schneider G, Sprenger GA and Samland AK: Acid-base catalyst discriminates between a fructose 6-phosphate aldolase and a transaldolase. ChemCatChem (2015) 7, 3186. 
doi: 10.1002/cctc.201500478

Vollmer B, Lorenz M, Moreno-Andres D, Astrinidis S, Schooley A, Flötenmeyer M, Leptihn S, and Antonin W. Nup153 recruits the Nup107-160 complex to the inner nuclear membrane for interphasic nuclear pore complex assembly. Developmental Cell (2015) 33, 717-728.
doi: 10.1016/j.devcel.2015.04.027

Lauber J, Handrick R, Leptihn S, Dürre P, and Gaisser S: Expression of the functional recombinant human glycosyltransferase GalNAcT2 in Escherichia coli. Microbial Cell Factories (2015) 14, 3.
“Highly Accessed”.
doi: 10.1186/s12934-014-0186-0

2013

Halang P, Leptihn S, Meier T, Vorburger T, and Steuber J. The function of the Na+-driven flagellum of Vibrio cholerae is determined by osmolality and pH. Journal of Bacteriology (2013) 195 (21), 4888-99. 
doi: 10.1128/JB.00353-13

Leptihn S, Castell OK, Cronin B, Lee EH, Gross LCM, Marshall DP, Thompson JR,  Holden M,  Wallace MI:  Droplet  Interface Bilayers: Constructing  artificial  lipid  bilayers from the contact of aqueous droplets in oil. Nature Protocols (2013) 8(6), 1048-57.
doi: 10.1038/nprot.2013.061

2011

Leptihn S, Thompson JR,  Ellory JC,  Tucker SJ,  and Wallace MI:  In  Vitro   Reconstitution  of  Eukaryotic  Ion Channels  Using  Droplet  Interface  Bilayers. Journal  of  the  American Chemical Society (2011) 133 (24), 9370-9375.
doi: 10.1021/ja200128n

2010

Leptihn S, Har JY, Wohland T and  Ding  JL: Correlation  of  charge,  hydrophobicity,  and  structure  with  antimicrobial activity   of  S1  and  MIRIAM  peptides. Biochemistry  (2010) 49,  9161-9170.
doi: 10.1021/bi1011578

Leptihn S, Guo L, Frecer V, Bo H, Ding JL, and Wohland T:  One  step  at  a  time:  Action  Mechanism  of  Sushi1  Antimicrobial  Peptide   and  Derived  Molecules. Virulence  (2010) 1 (1) 42-44.
doi: 10.4161/viru.1.1.10229

2009

Leptihn S,  JY  Har,  T.  Wohland,  J  Chen,  B.  Ho  and  JL  Ding: Single   molecule  resolution  of  the  antimicrobial  action  of  quantum  dot-labeled  sushi  peptide on  live bacteria. BMC  Biology (2009) 7, 22.
“Highly Accessed”. Evaluated by Faculty of 1000: “Must read”.
doi: 10.1186/1741-7007-7-22

2004

Falsone SF1, Leptihn S1, Osterauer A, Haselbeck M,  and Buchner J: Oncogenic Mutations  reduce  the Stability of Src Kinase, J Mol Biol. (2004) 344(1), 281-91. 1: equal contribution
doi: 10.1016/j.jmb.2004.08.091

2001

Maxwell IH, Chapman JT, Scherrer LC, Spitzer AL, Leptihn S, Maxwell F, Corsini JA. Expansion  of  tropism  of  a  feline  parvovirus  to target a human tumor cell line by  display  of an AV integrin binding peptide on the capsid. Gene Therapy (2001) 8, 324-31.
doi: 10.1038/sj.gt.3301399