2022
Fang Y, Wang N, Wu Z, Zhu Y, Ma Y, Li Y, Cai H, Zhang P, Leptihn S, Yu Y, Hua X, and Tu Y: An XDR Pseudomonas aeruginosa ST463 strain with an IncP-2 plasmid containing a novel transposon Tn6485f encoding blaIMP-45 and blaAFM-1 and a second plasmid with two copies of blaKPC-2. Microbiology Spectrum (DOI)
Hua X, He J, Shi Q, Chen Z, Zhang W, Xu Q, Lan P, Hu H, Chen Q, Fan J, Jiang Y, Loh B, Leptihn S, Zhang J and Yu Y: Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae. Drug Resistance Updates (DOI)
Shao M, Ying N, Liang Q, Ma N, Leptihn S, Yu Y, Chen H, Liu C, Hua X: Pdif-mediated Antibiotic resistance genes Transfer in Bacteria identified by pdifFinder. Briefings in Bioinformatics (DOI)
Liu X, Lei T, Yang Y, Zhang L, Liu H, Leptihn S, Yu Y, Hua H: Structural basis of PER-1-mediated cefiderocol resistance and synergistic inhibition of PER-1 by cefiderocol in combination with avibactam or durlobactam in Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy (DOI)
Manohar P, Loh B, Turner D, Tamizhselvi R, Mathankumar M, Elangovan N, Nachimuthu R, Leptihn S: In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. BioRxiv. doi: 10.1101/2022.10.12.512010 (in review)
Long Ma, Simon Roux, Xiaoting Hua, Yong Wang, Belinda Loh* and Leptihn S* (* co-corresponding): From motor protein to toxin: Mutations in the zonula occludens toxin (Zot) of Vibrio cholerae phage CTXɸ suggest a loss of phage assembly function.
Research Square. doi: 10.21203/rs.3.rs-2055679/v1 (review complete, revisions in progress for Nature Communications)
Manohar P, Loh B, Ramesh N, and Leptihn S: Phage-antibiotic combinations to control Pseudomonas aeruginosa- Candida albicans two-species biofilms.
BioRxiv. doi: 10.1101/2022.08.18.504394 (in review)
Manohar S, Loganathan A, Nachimuthu R, Loh B, Ma L, Leptihn S. Complete Genome Sequence of Pseudomonas phage Motto. Microbiology Resource Announcements.
DOI: 10.1128/mra.00740-22
Zhang L, Wang X, Hua X, Yu Y, Leptihn S, and Loh B (* co-corresponding): Therapeutic Evaluation of the Acinetobacter baumannii Phage Phab24 for Clinical Use.
Virus Research DOI: 10.1016/j.virusres.2022.198889
Liu M, Tian Y, Zaki H, Ahmed T, Yao R, Yan C, Leptihn S, Loh B, Shahid MS, Wang F, Chen J, Li B: Molecular Resistance Mechanism to Phage X2 Results in Decreased Pathogenicity of the Rice Pathogen Xanthomonas oryzae pv. oryzae Viruses DOI: 10.3390/v14081770
Ramesh N, Manohar P, Eniyan K, Archana L, Athira S, Loh B, Ma L, Leptihn S: A Lysozyme Murein Hydrolase with Broad-spectrum Antibacterial Activity from Enterobacter Phage myPSH1140. Antimicrobial Agents and Chemotherapy DOI: 10.1128/aac.00506-22
Zhao F, Liu H, Yao Y, Zhang L, Zhou Z, Leptihn S, Yu Y, Hua X, and Ying Fu : Emergence of a rare pyomelanin producer strain of carbapenem-resistant Acinetobacter baumannii co-harbouring chromosomal OXA-23 and NDM-1 in the intensive care unit. Microbiology Spectrum DOI: 10.1128/spectrum.02144-22
Arumugam SN, Manohar P, Sukumaran S, Sadagopan S, Loh B, Leptihn S, and Nachimuthu R: Antibacterial Efficacy of Lytic Phages against Multidrug-Resistant Pseudomonas aeruginosa Infections in Bacteraemia Mice Models. BMC Microbiology
DOI: 10.1186/s12866-022-02603-0
Zhang L, Fu Y, Zhang L, Xu Q, He J, Leptihn S, Loh B, Toleman M, Chen Q, Liu L, Yu Y, and Hua X: Co-evolutionary adaptations of Acinetobacter baumannii and a clinical carbapenemase encoding plasmid under carbapenem exposure. Evolutionary Applications https://doi.org/10.1111/eva.13441
Zhang W, Zhou H, Jiang Y, He J, Yao Y, Wang J, Liu X, Leptihn S, Hua X and Yu Y: Acinetobacter baumannii outer membrane protein A induces pulmonary epithelial barrier dysfunction and bacterial translocation through the TLR2/IQGAP1 axis. Frontiers in Immunology (accepted). https://doi.org/10.3389/fimmu.2022.927955
Yao Y, Zhou Q, Feng Y, Leptihn S, Yu Y, and Hua X: Complete genome sequence of Vibrio harveyi Strain ATCC 33866. Microbiology Resource Announcements https://doi.org/10.1128/mra.00073-22.
Wang S, Findeisen L, Leptihn S, Wallace MI, Hörning M, Nussberger S: Correlation of mitochondrial TOM core complex stop-and-go and open-closed channel dynamics. Communications Biology (2022), 5(1):471
Leptihn S and Loh B: Complexity, Challenges, and Costs of Implementing Phage Therapy. Future Microbiology (2022), 17:643-646 https://doi.org/10.2217/fmb-2022-0054
Fan J, Cai H, Fang Y, He J, Zhang L, Xu G, Yang Y, Leptihn S, Yu Y, Zhao D and Hua X: Molecular genetic characteristics of plasmid-borne mcr-9 in Salmonella enterica serotype Typhimurium and Thompson in Zhejiang, China. Frontiers in Microbiology (2022) 13:852434.
Manohar P, Loh B, Namasivayam E, Loganathan A, Nachimuthu R, Leptihn S. A multiwell-plate Caenorhabditis elegans assay for assessing the therapeutic potential of Bacteriophages against Clinical Pathogens. Microbiology Spectrum (2022) , 10, 1, e01393.
Manohar P, Royam MM, Loh B, Bozdogan B, Nachimuthu R, Leptihn S. Synergistic Effects of Phage-Antibiotic Combinations against Citrobacter amalonaticus. ACS Infectious Diseases (2022) 14;8(1):59-65.
doi: 10.1021/acsinfecdis.1c00117
Manohar P, Loh B, Namasivayam E, Loganathan A, Nachimuthu R, Leptihn S. A multiwell-plate Caenorhabditis elegans assay for assessing the therapeutic potential of Bacteriophages against Clinical Pathogens. bioRxiv (2022)
doi: 10.1101/2022.01.05.474866
2021
Loh B, Zhang L, Hua X, Yu Y, Long M, Wang X, Manohar P, Nachimuthu R, Martins WMBS, Toleman MA, Leptihn S. Complete Genome of the Virulent Klebsiella pneumoniae Phage Geezett Infecting Multidrug-Resistant Clinical Strains. Microbiology Resource Announcements. (2021) 10(48) e00685-21.
doi: 10.1128/MRA.00685-21
Loh B, Wang X, Hua X, Luo J, Wen T, Zhang L, Ma L, Manohar P, Nachimuthu R, Grainge I, Yu Y, Leptihn S. Complete genomes of Bacteriophages Kaya, Guyu, Kopi and TehO that target clinical strains of Pseudomonas aeruginosa. Microbiology Resource Announcements. (2021) 10(48) e01043-21.
doi: 10.1128/MRA.01043-21
Wang X, Loh B, Altamirano FG, Yu Y, Hua X, Leptihn S. Colistin-phage combinations decrease antibiotic resistance in A. baumannii via changes in envelope architecture. Emerging Microbes & Infections (2021) 1-58.
doi: 10.1080/22221751.2021.2002671
Loh B, Wang X, Hua X, Chook HW, Ma L, Zhang L, Manohar P, Jin Y, Leptihn S. Complete Genome of the Lytic Bacteriophage Phab24 that infects Clinical Strains of the Nosocomial Pathogen Acinetobacter baumannii. Microbiology Resource Announcements (2021) 10 (40) e00669-21.
doi: 10.1128/MRA.00669-21
Wang X, Loh B, Yu Y, Hua X, Leptihn S. Phage Resistance Mechanisms Increase Colistin Sensitivity in Acinetobacter baumannii. bioRxiv (2021)
doi: 10.1101/2021.07.23.453473
Swanson NA, Lokareddy RK, Li F, Leptihn S, Pumroy RA, Moiseenkova-Bell VY, Cingolani G. Cryo-EM Structure of the Periplasmic Tunnel of T7 DNA-Ejectosome at 2.70 Å resolution. Molecular Cell (2021) 81(15):3145-3159.e7.
doi: 10.1016/j.molcel.2021.06.001
Ramesh N, Royam MM, Manohar P, Leptihn S. Application of Bacteriophages and Endolysins in Aquaculture as a Biocontrol Measure. Biological Control (2021) 160, 104678.
doi: 10.1016/j.biocontrol.2021.104678
Zhu Y, Chen J, Shen H, Chen Z, Yang QW, Zhu J, Li X, Yang Q, Zhao F, Ji J, Cai H, Li Y, Zhang L, Leptihn S, Hua X, Yu Y. Emergence of Ceftazidime- and Avibactam-Resistant Klebsiella pneumoniae Carbapenemase-Producing Pseudomonas aeruginosa in China. mSystems. (2021) 6(6):e0078721.
doi: 10.1128/mSystems.00787-21
He J, Sun L, Zhang L, Leptihn S, Yu Y, Hua X. A Novel SXT/R391 Integrative and Conjugative Element Carries Two Copies of the blaNDM-1 Gene in Proteus mirabilis. mSphere (2021) 6(4):e0058821.
doi: 10.1128/mSphere.00588-21
Das R, Kotra K, Singh P, Loh B, Leptihn S, Bajpai U. Alternative Treatment Strategies for Secondary Bacterial and Fungal Infections Associated with COVID-19. Infectious Diseases & Therapy (2021) 1–25.
doi: 10.1007/s40121-021-00559-8
Olubusola OO, Onogu AN, Ray JA, Olorundare O, Ezemokwe GC, Nnadi UP, Agwom F, Morenikeji OR, Nanko G, Ngene AC, Aguiyi JC, Leptihn S, Nnadi NE. Draft Genome Sequence of Salmonella enterica Serovar Enteritidis from Jos, Plateau State, Nigeria. Microbiology Resource Announcements. (2021) 10(48):e0057621.
doi: 10.1128/MRA.00576-21
Wu Z, Zhang Y, Xu X, Ahmed T, Yang Y, Loh B, Leptihn S, Yan C, Chen J, Li B. The holin-endolysin lysis system of the OP2-like phage infecting Xanthomonas oryzae pv. oryzae. Viruses (2021) 13, 1949.
doi: 10.3390/v13101949
Cui Z, Zhang Y, Kakar KU, Kong X, Li R, Loh B, Leptihn S, Li B. Involvement of non-coding RNAs during infection of rice by Acidovorax oryzae. Environmental Microbiology Reports (2021) 13(4), 540-554
doi: 10.1111/1758-2229.12982
Chen H, Hua X, Liang Q, He J, He J, Wang M, Hong W, We J, Lu B, Leptihn S, Yu Y. BacAnt: A Combination Annotation Server for Bacterial DNA sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements. Frontiers in Microbiology (2021) 12, 2015.
doi: 10.3389/fmicb.2021.649969
Cai H, Zhu Y, Hu D, Li Y, Leptihn S, Loh B, Hua X, Yu Y. Co-harboring of novel hybrid blaKPC−2 plasmid and ICE carrying Tn6203 in multidrug-resistant Pseudomonas aeruginosa. Frontiers in Microbiology (2021) 12:674974.
doi: 10.3389/fmicb.2021.674974
Wang X, Zhang M, Loh B, Leptihn S, Ahmed T, Li B. A Novel NRPS Cluster, Acquired by Horizontal Gene Transfer from Algae, Regulates Siderophore Iron Metabolism in Burkholderia seminalis R456. International Journal of Biological Macromolecules (2021) 182,838-848
doi: 10.1016/j.ijbiomac.2021.04.051
Feng T, Leptihn S, Dong K, Loh B, Zhang Y, Li M, Guo XK, Zelin Cui. JD419, a Staphylococcus aureus phage with a unique morphology and broad host range. Frontiers in Microbiology (Virology) (2021) 12,602902
doi: 10.3389/fmicb.2021.602902
Wang Y, Liang Q, Lu B, Shen H, Liu S, Shi Y, Leptihn S, Li H, Wei J, Liu C, Xiao H, Zheng X, Liu C, Chen H. Whole-genome analysis of probiotic product isolates reveals the presence of genes related to antimicrobial resistance, virulence factors, and toxic metabolites, posing potential health risks. BMC Genomics (2021) 22, 210
doi: 10.1186/s12864-021-07539-9
Manohar P, Leptihn S, Lopes BS, Nachimuthu R. Dissemination of carbapenem resistance and plasmids encoding carbapenemases in Gram-negative bacteria isolated in India. JAC-Antimicrobial Resistance (2021) 3(1) dlab015
doi: 10.1093/jacamr/dlab015
Manohar P, Nachimuthu R, Leptihn S, Anuradha R, Rudi K. Reduced Metagenomic Sequencing (RMS) Approach to Determine the Gut-Associated Phageome in Mother-Child. Human Microbiome Journal (2021) 100078
doi: 10.1016/j.humic.2021.100078
Wei W, Yao X, Zhou W, Wang X, Li C, Lin J, Ma Y, He Q, Leptihn S, and Ouyang H. Advanced Hydrogels for the Repair of Cartilage Defects and Regeneration. Bioactive Materials (2021) 6(4), 998-1011.
doi: 10.1016/j.bioactmat.2020.09.030
2020
Loh B*, Gondil VS*, Manohar P, Khan FM, Yang H, Leptihn S. Encapsulation and Delivery of Therapeutic Phages. Applied and Environmental Microbiology (2020) 87:e01979-20.
doi: 10.1128/AEM.01979-20.
Leptihn S, Welburn SC. Will technology rather than vaccination be the way to control pandemics? Infectious Microbes & Diseases (2020) 2(4), 125-126.
doi: 10.1097/IM9.0000000000000041
Fang J, Zhang L, He J, Zhao M, Loh B, Leptihn S, Yu Y, Hua X. Plasmid dynamics of mcr-1-positive Salmonella spp. in a general hospital in China. Frontiers in Microbiology (2020) 11, 3320.
doi: 10.3389/fmicb.2020.604710
Loh B*, Chen J*, Manohar P, Yu Y, Hua X, Leptihn S. A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. Frontiers in Microbiology (2020) 11, 3055.
doi: 10.3389/fmicb.2020.579802
Feng T, Leptihn S, Dong K, Loh B, Zhang Y, Li M, Guo X, Cui Z. Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range. bioRxiv (2020)
doi: 10.1101/2020.11.09.370866
Hua X, Xu Q, He J, Zhang D, Chen Q, Zhang L, Loh B, Leptihn S, Wen Y, Higgins P, Zhou Z, Yu Y. The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China. International Journal of Medical Microbiology (2020) 310(8), 151464.
doi: 10.1016/j.ijmm.2020.151464
Loh B*, Chen J*, Manohar P, Yu Y, Hua X, Leptihn S. A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. bioRxiv (2020)
doi: 10.1101/2020.10.26.355222
Manohar P, Loh B, Leptihn S. Will the overuse of Antibiotics during the Coronavirus pandemic accelerate Antimicrobial resistance? Infectious Microbes & Diseases (2020) 2(3), 87-88.
doi: 10.1097/IM9.0000000000000034
Hua X, Liang Q, He J, Wang M, Hong W, Wu J, Lu B, Leptihn S, Yu Y, Chen H. BacAnt: the combination annotation server of antibiotic resistance gene, insertion sequences, integron, transposable elements for bacterial DNA sequences. bioRxiv (2020)
doi: 10.1101/2020.09.05.284273
Manohar P, Loh B, Nachimuthu R, Hua X, Welburn SC, Leptihn S. Secondary Bacterial Infections in Patients with Viral Pneumonia. Frontiers in Medicine (2020) 7, 420.
doi: 10.3389/fmed.2020.00420
Manohar P, Loh B, Athira S, Nachimuthu R, Hua X, Welburn SC, Leptihn S. Secondary Bacterial Infections during Pulmonary Viral Disease: Phage Therapeutics as Alternatives to Antibiotics? Frontiers in Microbiology (2020) 11, 1434.
doi: 10.3389/fmicb.2020.01434
Hua X, Zhang L, He J, Leptihn S, Yunsong Yu. Population biology and epidemiological studies of Acinetobacter baumannii in the era of Whole Genome Sequencing: Is the Oxford scheme still appropriate? Frontiers in Microbiology (2020) 11, 775.
doi: 10.3389/fmicb.2020.00775
Loh B and Leptihn S: A call for a multidisciplinary future of Phage Therapy to combat multi-drug resistant bacterial infections. Infectious Microbes & Diseases (2020) 2(1), 1-2.
doi: 10.1097/IM9.0000000000000018
Hua X, Liang Q, Fang L, He J, Wang M, Hong W, Leptihn S, Wang H, Yu Y, and Chen H: Bautype-Capsule and Lipopolysaccharide Serotype Prediction for Acinetobacter baumannii Genomes. Infectious Microbes & Diseases (2020) 2(1), 18-25.
doi: 10.1097/IM9.0000000000000019
Feng T, Leptihn S, Li M, Guo M, Gao J, Li Q, Zeng L, Zhou Y, Wei Y, Guo X, Temperton N, Cui Z. Feasibility for SARS-CoV-2 Tests in the Hospital: An Exposure Analysis of Critical Control Points Approach. Research Square (2020)
doi: 10.21203/rs.3.rs-33080/v1
Shi Y, Hua X, Xua Q, Yang Y, Zhang L, He J, Mu X, Hu L, Leptihn S, Yu Y: Mechanism of eravacycline resistance in Acinetobacter baumannii mediated by a deletion mutation in the sensor kinase adeS, leading to elevated expression of the efflux pump AdeABC. Infection, Genetics and Evolution (2020), 80, 104185.
doi: 10.1016/j.meegid.2020.104185
Hu L, Shi Y, Xu Q, Zhang L, He J, Jiang Y, Liu L, Leptihn S, Yu Y, Hua X, Zhou Z: Capsule thickness, not biofilm formation, gives rise to mucoid Acinetobacter baumannii phenotypes that are more prevalent in long-term infections. A study of clinical isolates from a hospital in China. Infection and Drug Resistance (2020) 13, 99—109.
doi: 10.2147/IDR.S230178
Zhao K, Liu YS, Nie LY, Qian LN, Nie NF, Leptihn S, Bunpetch V, Xu JQ, Zhou XH, Ouyang H: The Influence of Sample Size and Gender Composition on the Meta-analysis Conclusion of Platelet-Rich Plasma Treatment for Osteoarthritis Journal of Orthopaedic Translation (2020) 22, 34-42.
doi: 10.1016/j.jot.2019.10.002
2019
Kuhn A. and Leptihn S: Helical and Filamentous Phages. Encyclopaedia of Virology (2019)
Hardcover ISBN: 9780122270307 ; eBook ISBN: 9780080547978
doi: 10.1016/B978-0-12-809633-8.20986-2
Leptihn S: Welcome back to the Pre-Penicillin Era. Why we desperately need new strategies in the battle against bacterial pathogens. Infectious Microbes & Diseases (2019) 1(2), 33.
doi: 10.1097/IM9.0000000000000009
Manohar P, Tamhankar AJ, Leptihn S, and Ramesh N: Pharmacological and Immunological Aspects of Phage Therapy. Infectious Microbes & Diseases (2019) 1(2), 34-42.
doi: 10.1097/IM9.0000000000000013
Xu Q, Chen T, Yan B, Zhang L, Pi B, Yang Y, Zhang L, Zhou Z, Ji S, Leptihn S, Akova M, Yu Y, Hua X: Dual role of gnaA in antibiotic resistance and virulence in Acinetobacter baumannii. Antimicrobial Agents Chemotherapy (2019) 23, 63(10).
doi: 10.1128/AAC.00694-19
Loh B, Kuhn A and Leptihn S: The fascinating biology behind phage display: Filamentous Phage Assembly. Molecular Microbiology (2019) 111(5), 1132.
doi: 10.1111/mmi.14187
Volk V, Glück C, Leptihn S, Ewert J, Stressler T and Fischer L: Two heat resistant endopeptidases from Pseudomonas species with destabilizing potential during milk storage. Journal of Agricultural and Food Chemistry (2019) 67, 905.
doi: 10.1021/acs.jafc.8b04802
2018
Mueller P, Gauttam R, Raab N, Handrick R, Wahl C, Leptihn S, Zorn M, Kussmaul M, Scheffold M, Eikmanns B, Elling L, Gaisser S: High level in vivo mucin-type glycosylation in Escherichia coli Microbial Cell Factories (2018) 17(1), 168.
doi: 10.1186/s12934-018-1013-9
Stressler T, Reichenberger K, Glück C, Leptihn S, Pfannstiel J, Swietalski P, Kuhn A, Seitl I, Fischer L.: A natural variant of arylsulfatase from Kluyveromyces lactis shows no formylglycine modification and has no enzyme activity. Appl Microbiol Biotechnol. (2018) 102(6), 2709.
doi: 10.1007/s00253-018-8828-5
Ernst I, Haase M, Ernst S, Yuan S, Kuhn A, and Leptihn S: Large conformational changes of a highly dynamic pre-protein binding domain in SecA. Communications Biology (2018) 1 (1), 130.
doi: 10.1038/s42003-018-0133-4
Gras C, Bause K, Leptihn S, Carle R, Schweiggert RM: Effect of chlorogenic acid on spectral properties and stability of acylated and non-acylated cyanidin-3-O-glycosides. Elsevier Food Chemistry (2018) 240, 940.
doi: 10.1016/j.foodchem.2017.07.137
2017
Leptihn S: Interaction of Polypeptides with Phospholipid Membranes (Habilitation) Monograph (2017)
Kuhn A, Haase M, and Leptihn S: Assisted and unassisted protein insertion into liposomes. Biophysical Journal (2017) 113 (6), 1187.
doi: 10.1016/j.bpj.2017.03.027
Loh B, Haase M, Mueller L, Kuhn A, and Leptihn S: The transmembrane morphogenesis protein gp1 of filamentous phages contains Walker A and Walker B motifs essential for phage assembly. Viruses (2017) 9 (4), 73.
doi: 10.3390/v9040073
Altrichter S, Haase M, Loh B, Kuhn A and Leptihn S: Mechanism of the Spontaneous and Directional Insertion of a 2-Transmembrane Ion Channel. ACS Chemical Biology (2017) 12 (2), 380-388.
doi: 10.1021/acschembio.6b01085
2016
Meyer M, Leptihn S, Welz M, and Schaller A: Functional characterization of propeptides in plant subtilases as molecular chaperones and inhibitors of the mature protease. Journal of Biological Chemistry (2016) 291 (37), 19449-61.
doi: 10.1074/jbc.M116.744151
Utturkar S, Huber H, Leptihn S, Loh B, Brown S, Stetter KO and Podar M: Draft-Genome sequence of Pyrodictium occultum PL-19, a marine hyperthermophilic species of Archaea that grows at 105˚C. American Society for Microbiology: Genome Announcements (2016) 25 4(1).
doi: 10.1128/genomeA.00016-16
Leptihn S*, Gottschalk J, and Kuhn A. The T7 Ejectosome: A story unfolds. Bacteriophage (2016), 6, 1. * corresponding author.
doi: 10.1080/21597081.2015.1128513
Hempel J, Schaedle C, Leptihn S, Carle R, and Schweiggert RM: Structure related aggregation behavior of carotenoids and carotenoids esters. Journal of Photochemistry and Photobiology A: Chemistry (2016) 317, 161-174.
doi: 10.1016/j.jphotochem.2015.10.024
2015
Lupo D, Leptihn S, Nagler G, Haase M, Molineux IJ, and Kuhn A: The T7 ejection nanomachine components gp15-gp16 form a spiral ring complex that binds DNA and a lipid membrane. Virology (2015) 14(486), 263-271.
doi: 10.1016/j.virol.2015.09.022
Stellmacher L, Sandalova T, Leptihn S, Schneider G, Sprenger GA and Samland AK: Acid-base catalyst discriminates between a fructose 6-phosphate aldolase and a transaldolase. ChemCatChem (2015) 7, 3186.
doi: 10.1002/cctc.201500478
Vollmer B, Lorenz M, Moreno-Andres D, Astrinidis S, Schooley A, Flötenmeyer M, Leptihn S, and Antonin W. Nup153 recruits the Nup107-160 complex to the inner nuclear membrane for interphasic nuclear pore complex assembly. Developmental Cell (2015) 33, 717-728.
doi: 10.1016/j.devcel.2015.04.027
Lauber J, Handrick R, Leptihn S, Dürre P, and Gaisser S: Expression of the functional recombinant human glycosyltransferase GalNAcT2 in Escherichia coli. Microbial Cell Factories (2015) 14, 3.
“Highly Accessed”.
doi: 10.1186/s12934-014-0186-0
2013
Halang P, Leptihn S, Meier T, Vorburger T, and Steuber J. The function of the Na+-driven flagellum of Vibrio cholerae is determined by osmolality and pH. Journal of Bacteriology (2013) 195 (21), 4888-99.
doi: 10.1128/JB.00353-13
Leptihn S, Castell OK, Cronin B, Lee EH, Gross LCM, Marshall DP, Thompson JR, Holden M, Wallace MI: Droplet Interface Bilayers: Constructing artificial lipid bilayers from the contact of aqueous droplets in oil. Nature Protocols (2013) 8(6), 1048-57.
doi: 10.1038/nprot.2013.061
2011
Leptihn S, Thompson JR, Ellory JC, Tucker SJ, and Wallace MI: In Vitro Reconstitution of Eukaryotic Ion Channels Using Droplet Interface Bilayers. Journal of the American Chemical Society (2011) 133 (24), 9370-9375.
doi: 10.1021/ja200128n
2010
Leptihn S, Har JY, Wohland T and Ding JL: Correlation of charge, hydrophobicity, and structure with antimicrobial activity of S1 and MIRIAM peptides. Biochemistry (2010) 49, 9161-9170.
doi: 10.1021/bi1011578
Leptihn S, Guo L, Frecer V, Bo H, Ding JL, and Wohland T: One step at a time: Action Mechanism of Sushi1 Antimicrobial Peptide and Derived Molecules. Virulence (2010) 1 (1) 42-44.
doi: 10.4161/viru.1.1.10229
2009
Leptihn S, JY Har, T. Wohland, J Chen, B. Ho and JL Ding: Single molecule resolution of the antimicrobial action of quantum dot-labeled sushi peptide on live bacteria. BMC Biology (2009) 7, 22.
“Highly Accessed”. Evaluated by Faculty of 1000: “Must read”.
doi: 10.1186/1741-7007-7-22
2004
Falsone SF1, Leptihn S1, Osterauer A, Haselbeck M, and Buchner J: Oncogenic Mutations reduce the Stability of Src Kinase, J Mol Biol. (2004) 344(1), 281-91. 1: equal contribution
doi: 10.1016/j.jmb.2004.08.091
2001
Maxwell IH, Chapman JT, Scherrer LC, Spitzer AL, Leptihn S, Maxwell F, Corsini JA. Expansion of tropism of a feline parvovirus to target a human tumor cell line by display of an AV integrin binding peptide on the capsid. Gene Therapy (2001) 8, 324-31.
doi: 10.1038/sj.gt.3301399
The Leptihn Lab 